Ionic liquid combined with bile acid pathway for oral delivery of rhGH

Oral absorption and room temperature storage remain two major challenges limiting the bioavailability of recombinant human growth hormone (rhGH) due to need overcome unfavorable gastrointestinal environment resist effects on rhGH structure, Therefore, we designed a multifunctional nanoplatform address both problems simultaneously. The carrier consists PLGA, ionic liquid (IL) deoxycholic acid (DCA). In this nanosystem, IL acts as green non-toxic solvent helps nanoparticles open tight junctions between cells, protectant improve stability rhGH. Endogenous DCA ligand increases intestinal through receptor-mediated endocytosis. have following advantages: 1) Protects in tract from being degraded by gastric proteases. 2) was increased its enhanced. 3) time at prolonged. These materials are cheap, readily available easily synthesized these studies provide basis for clinical application